BY
Hala M. Hussein ,Madeha M. Abd El-Kader,  and Saeham A. Kasem

Nutrition Department, National Research Center, Dokki, Cairo, Egypt

ABSTRACT

Objectives: To evaluate the potential effects of whole flaxseed (FS), and/or flax oil (FO) incorporation into the diet on the level of pro-inflammatory cytokines in ovariectomized (OVX) rats model of osteoporosis.

Methods: This study was performed in the Food Science Agriculture Collage, King Saud University, Kingdom, of Saudi Arabia from October to   December 2009. Fortyeight month-old female Sprague-Dawley rats were +randomly divided into 6 groups: Group 1 - sham control diet; OVX + 20% whole FS; Group 4 - OVX rats + 40% FSGroup 2    OVX rats + basal diet; Group 3 Group 5 - OVX rats + 5% FO; Group 6 - OVX rats

10 % FO. All OVX rats underwent bilateral ovariectomy The experiment was continued for 2 months. Serum bone alkaline phosphatase (B-ALP), interleukin-6 (IL 6), tumor necrosis factor-alpha (TNF-α), calcium (Ca),phosphorous (P), and magnesium (Mg) were measured.-